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Cells produce ROS during normal aerobic respiration, and superoxide dismutase (SOD) in the cells catalyzes the conversion of superoxide anions (O 2 ) into hydrogen peroxide (H 2 O 2 ) and oxygen (O 2 ), thereby detoxifying ROS

CircACC1 is a circRNA derived from the human acetyl-CoA carboxylase 1 ( ACC1 ) gene and directly binds to the and subunits of AMPK, facilitating its activity, 279 and promoting glycolysis and fatty acid -oxidation during metabolic stress

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